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Jun 25, 2026

Joe Manganiello details ‘brutal side effects’ of secret health battle: ‘I suffered in silence’

Joe Manganiello details 'brutal side effects' of secret health battle Email Page Six

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Joe Manganiello details ‘brutal side effects’ of secret health battle: ‘I suffered in silence’

By Antoinette Bueno Published June 24, 2026, 10:08 p.m. ET

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Joe Manganiello revealed more about his alarming health battle that he kept secret for almost a decade.

The “True Blood” alum, in an Instagram video Wednesday, said he “suffered in silence battling a deadly mystery illness” he only told a small circle of loved ones about. He recalled seeing “the best doctors in the world,” whom he said couldn’t figure out what started his condition.

“All their attempts to treat it with high-powered biological drugs only exacerbated my symptoms and then unlocked a host of brutal side effects that winded up plaguing me for years,” Manganiello said.

“And then in attempts to buy myself time,” he continued, “I underwent very serious operations and procedures that mutilated parts of my body and left me so weak at times that I couldn’t stand up or walk.”

Joe Manganiello speaking about his secret health battle. 6
Joe Manganiello revealed more about his secret illness he battled for almost a decade in an Instagram video Wednesday (a screenshot of which is seen above). Instagram/Joe Manganiello
Joe Manganiello wearing a gray hooded sweatshirt, looking directly at the camera. 6
The “True Blood” alum (seen here in the social media post) said doctors couldn’t figure out what started his illness but prescribed him “high-powered biological drugs” that gave him “brutal side effects.” Instagram/Joe Manganiello

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The “Magic Mike” alum, 49, also shared that he spent months “heavily medicated while dealing with excruciating bouts of chronic pain.” He noted that his upcoming memoir, “Bloodlines,” out Oct. 13, documents his 10-year search for answers as well as a deep dive into his family’s history.

“Maybe what happened to me wasn’t random,” he says. “And that in order to heal, my mind, my body, my spirit all had to align and I needed to become open to some really radical and unorthodox techniques and ideas that lie beyond the boundaries of western medicine.”

Manganiello shared a supportive message for those who might be going through a similar situation.

“If you’re out there and you’re suffering, there’s hope,” he said.

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Manganiello — pictured here in March 2025 — said he dealt with the side effects for years and also underwent operations that “mutilated” parts of his body. Getty Images
Black and white close-up of Joe Manganiello's face, with a greying beard and intense stare, on the cover of his memoir, "Bloodlines". 6
His upcoming memoir, “Bloodlines” (the cover of which is seen here), documents his illness and the alternative treatments he sought. Simon & Schuster

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