Joe Manganiello details ‘brutal side effects’ of secret health battle: ‘I suffered in silence’
Joe Manganiello details 'brutal side effects' of secret health battle
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Shop Prime Day like a star with deals on A-list beauty favorites: Crest, Charlotte Tilbury and more Celebrity NewsJoe Manganiello details ‘brutal side effects’ of secret health battle: ‘I suffered in silence’
By Antoinette Bueno Published June 24, 2026, 10:08 p.m. ETSee more of our coverage in your search results.
Add Page Six on GoogleJoe Manganiello revealed more about his alarming health battle that he kept secret for almost a decade.
The “True Blood” alum, in an Instagram video Wednesday, said he “suffered in silence battling a deadly mystery illness” he only told a small circle of loved ones about. He recalled seeing “the best doctors in the world,” whom he said couldn’t figure out what started his condition.
“All their attempts to treat it with high-powered biological drugs only exacerbated my symptoms and then unlocked a host of brutal side effects that winded up plaguing me for years,” Manganiello said.
“And then in attempts to buy myself time,” he continued, “I underwent very serious operations and procedures that mutilated parts of my body and left me so weak at times that I couldn’t stand up or walk.”
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The “Magic Mike” alum, 49, also shared that he spent months “heavily medicated while dealing with excruciating bouts of chronic pain.” He noted that his upcoming memoir, “Bloodlines,” out Oct. 13, documents his 10-year search for answers as well as a deep dive into his family’s history.
“Maybe what happened to me wasn’t random,” he says. “And that in order to heal, my mind, my body, my spirit all had to align and I needed to become open to some really radical and unorthodox techniques and ideas that lie beyond the boundaries of western medicine.”
Manganiello shared a supportive message for those who might be going through a similar situation.
“If you’re out there and you’re suffering, there’s hope,” he said.
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In a synopsis for “Bloodlines,” Manganiello shares that he dealt with “a cascade of autoimmune-related illnesses” that attacked his thyroid, digestive system, skin, lungs and eyes.
Over the course of seven years, he revealed that he dealt with “chronic pain, a life-saving organ amputation, existential crisis and a prolonged fight for survival that left doctors with few answers and no clear explanation.”
Manganiello ended up turning to alternative medicine like “shamans, pagan rituals, ancient myths, long-lost family records and the rebirth of his own spirituality” to help treat his illness.
The former “Deal or No Deal Island” host also did intensive research into his own family genealogy and discovered ancestors who survived the Armenian genocide and others who lived with chronic illness.
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Manganiello has not revealed the years his health battle occurred.
He was previously married to actress Sofía Vergara, 53, from 2015 to 2024. The “Modern Family” alum said in January 2024 that the two split because she didn’t want to have kids with him and be “an old mom.”
“I feel it’s not fair to the baby,” she told El País.
Vergara is already a mom to her son, 34-year-old Manolo, whom she shares with ex-husband Joe Gonzalez.
Manganiello is now engaged to actress Caitlin O’Connor, 36, which the couple announced last October.
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Badenoch blasts 'moaning' female Labour MPs over Burnham jobs 'quota'

Kemi Badenoch has told Labour women to earn a job in Andy Burnham's Cabinet instead of demanding they are handed jobs because of their gender.
The Tory leader lashed out today amid reports that female MPs are demanding the de-facto new prime minister introduce a 50:50 gender split 'quota' in his government.
Amid reports that former foreign secretary David Miliband is being lined up to return to the role, possibly with his brother Ed as Chancellor, one female minister also complained that Burnham could not have 'more Milibands than women' in the top posts.
But in a scathing article in the Times today Mrs Badenoch told them to 'stop moaning' and get chosen on merit instead of retreating into 'more of the failed identity politics that is holding back our country'.
'There are many, many reasons why you shouldn't have any Milibands in the cabinet,' she said.
'But complaining that the boys haven't given them the right jobs or that the boys are taking all the jobs, just shows that Labour's women still don't get it.'
The idea of quotas was also attacked by Baroness Jacqui Smith, Labour's Skills Minister.
Asked by Times Radio if Mr Burnham should reserve jobs for women, she said: 'No, I think what Andy Burnham should be doing is building the very best team around him to change this country.'
A letter written by the Women's Parliamentary Labour Party has called on Mr Burnham to ensure a 50:50 split between men and women in government jobs
Amid reports that former foreign secretary David Miliband (above, right, in 2010) is being lined up to return to the role, possibly with his brother Ed as Chancellor, one female minister complained that Burnham could not have 'more Milibands than women' in the top posts
But Mrs Badenoch told them to pipe down and get chosen on merit instead of retreating into 'more of the failed identity politics that is holding back our country'
A letter written by the Women's Parliamentary Labour Party and seen by the BBC has called on Mr Burnham to ensure a 50:50 split between men and women in government jobs after he succeeds Sir Keir Starmer.
'We are asking you to demonstrate this change from day one and address the toxicity and misogyny within our own party and government,' it said.
Labour has never had a female leader, while the Conservatives have had three, and Mrs Badenoch urged the government to follow its meritocratic example.
'If you run a meritocracy, then you do not have to worry about jobs for the boys,' she wrote.
'Every woman who is a Conservative MP, every woman who has ever won the leadership, has had to fight to get where she is.
'By contrast, Labour women are demanding guarantees from Burnham. But the truth is he doesn't have to give any guarantees.
'If none of Labour's women are prepared to get their hands dirty and challenge him for the leadership, their demands are toothless.'
'In fact, it's quite revealing that the women's parliamentary Labour Party has written to Burnham asking him to commit himself to at least 50 per cent female ministers.
'This has nothing to do with meritocracy. It is yet more of the failed identity politics that is holding back our country.'
